UniServe Science Biology Table of Contents

9.7 Genetics: The Code Broken?
Structure of a gene Multiple alleles and polygenic inheritance Inheritance of genes
Human Genome Project Gene therapy Mechanisms of genetic changes
Selective breeding Cloning Gene expression

General

Ciliates in the Classroom - a joint effort by ciliate biologists to provide classroom protocols, background information and web links for instructors interested in using ciliates in their classroom
http://www.wooster.edu/biology/Ciliates/Ciliates_in_the_Classroom.html

DNA Interactive - from Cold Springs Harbor Laboratory
http://www.dnai.org/

Blazing a Genetic Trail - from Howard Hughes Medical Institute
http://www.hhmi.org/genetictrail/

DNA Structure - from Nobel prize.org
http://nobelprize.org/educational_games/medicine/dna/b/replication/dna_structure.html

Structure of a gene

To Know Ourselves - from the US Department of Energy and the Human Genome Project includes Introducing the Human Genome and Exploring the Genomic Landscape
http://www.ornl.gov/hgmis/publicat/tko/

What the Heck is a Gene? - from Microbiology, University of Kansas
http://people.ku.edu/~jbrown/gene.html

The Science Behind the Human Genome Project - from the Human Genome Program
http://www.ornl.gov/hgmis/project/info.html


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Multiple alleles and polygenic inheritance

Polymorphisms - by John W. Kimball, formerly of Harvard University, with links to blood typing and RH factor
http://www.ultranet.com/~jkimball/BiologyPages/P/Polymorphisms.html

An Introduction to the GENES that Influence Coat Color in Afghan Hounds - in Afghan Hounds, from a private breeder
http://www.hosanna1.com/Genetics/

You will learn about breeding cats and basic genetics of cats - from European Cat Fancy
http://www.geocities.com/Heartland/hollow/1991/genetic/

Gouldian Finch Free Genetics Software - from Lady Gouldian Finch.com
http://www.ladygouldianfinch.com/features_software.mgi?mgiToken=CDG2D19IHF4423J10JK

Gouldian Finches - from Beautiful Birdies
http://www.kairosnewsletter.net/bb/gouldianfinches.htm

Breeding Bugies: A lesson in genetics - from CentralPets.com
http://www.centralpets.com/php/search/storiesdisplay.php?Story=37

The Eastern Rosella: The Primary Colour Varieties - from BirdHobbyist
http://www.birdhobbyist.com/parrotcolour/gmr/gmr-varts.html


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Inheritance of genes

Introduction to genetics - from ThinkQuest Library
http://library.thinkquest.org/C004367/be1.shtml  

THOMAS HUNT MORGAN AT COLUMBIA UNIVERSITY - Genes, Chromosomes, and the Origins of Modern Biology, includes details of Sturetevant's work on Linkage mapping. - from Columbia University.
http://www.columbia.edu/cu/alumni/Magazine/Legacies/Morgan/index.html


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Human Genome Project

Human Genome Project and Genomic Research
http://www.ornl.gov/TechResources/Human_Genome/home.html

A New Gene Map of the Human Genome - from National Institute of Health, click on the appropriate chromosone number, or search on a key work
http://www.ncbi.nlm.nih.gov/genemap99/

Human Genome Project - from The Gene School
http://library.thinkquest.org/19037/genome.html

Genes and Disease - from National Institute of Health, click on a chromosome and see a map of the chromosome with diseases that are related to the genes
http://www.ncbi.nlm.nih.gov/disease/

Understanding Gene Testing - from Access Excellence and the National Institute of Health
http://www.accessexcellence.org/AE/AEPC/NIH/

Facing Your Genetic Destiny - an Exploration from Scientific American
http://www.sciam.com/article.cfm?articleID=00016A09-BE5F-1CDA-B4A8809EC588EEDF

GENES, DREAMS, AND REALITY The promises and risks of the NEW GENETICS - an article by Denise Casey in Judicature, Genes and Justice: The Growing Impact of the New Genetics on the Courts
http://www.ornl.gov/hgmis/publicat/judicature/article3.html

The Bioinformatics Gold Rush - an article from Scientific American, "turning raw genome data into knowledge for making new drugs"
http://www.sciam.com/article.cfm?articleID=00091CE8-3711-1C74-9B81809EC588EF21


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Gene therapy

Gene Therapy - from Human Genome Project Information including definition, hurdles, ethics as well as lists of articles
http://www.ornl.gov/hgmis/medicine/genetherapy.html

Gene Therapy - from The Gene School
http://library.thinkquest.org/19037/therapy.html

Human genetics: A Resource for Teachers - lists genetic diseases categorised under the following headings autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive, Y-linked, chromosomal and multi-factorial with suggestions for class activities and links including gene therapy
http://www.usoe.k12.ut.us/curr/science/core/bio/genetics/

Vantage Gene Therapy - from the Vanderbilt University Medical Center includes Gene Therapeutics - for Pulmonary Disease, Oncology, Cardiology and Neurological Disease
http://www.mc.vanderbilt.edu/gcrc/gene/

Gene Therapy - An Overview - from Access Excellence
http://www.accessexcellence.org/AB/IWT/Gene_Therapy_Overview.html

PROGRESS IN HEART DISEASE GENE THERAPY - from Access Excellence and the American Heart Association
http://www.accessexcellence.org/WN/SUA08/aha111.html

Human Gene Testing - from Beyond Discovery, The National Academy of Sciences
http://www.beyonddiscovery.org/content/view.article.asp?a=239

Gene Therapy - from Oak Ridge National Laboratory
http://www.ornl.gov/sci/techresources/Human_Genome/medicine/genetherapy.shtml

Gene Therapy Deaths - from Access Excellence
http://www.accessexcellence.org/WN/SU/genedeath1199.html

Gene Therapy to Prevent Hypertension - from Access Excellence
http://www.accessexcellence.org/WN/SU/genebp1199.html

Gene Repair for Muscular Dystrophy - a Newswise abstract of a Nature Biotechnology article
http://www.newswise.com/articles/2000/5/GOLDEN.NBT.html

Gene Expression - from Cancer Research at Huntsman Cancer Institute
http://www.huntsmancancer.org/research/graduateStudies~/gradStudies/geneExp.jsp

Regulation of Gene Expression - from YOUNG LAB, Whitehead Institute
http://web.wi.mit.edu/young/pub/regulation.html

Regulation of Gene Expression: Building Transcriptional Regulatory Complexes - from Access Excellence
http://www.accessexcellence.org/LC/ST/st09bg.html

Gene sponge treats broken bones - from BBC News Online: Health
http://news.bbc.co.uk/low/english/health/newsid_380000/380434.stm


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Mechanisms of genetic changes

Mutations and DNA Repair mechanisms -detailed point form Lecture Summary, from University of Wyoming
http://w3.uwyo.edu/%7Eannesyl/lecture22.html
Mutation, Mutagens, and DNA Repair - from Beth Montelone PhD, Division of Biology, Kansas State University, excellent notes on types of mutations and mutagens
http://www-personal.ksu.edu/~bethmont/mutdes.html

Barbara McClintock and Transposable Genetic Elements - from Office of Scientific & Technical Information
http://biocrs.biomed.brown.edu/Books/Essays/JumpingGenes.html

Researchers Trace Evolution to Relatively Simple Genetic Changes - evolution of Stickleback fish
http://www.hhmi.org/news/pdf/kingsley4.pdf


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Selective breeding

Ethics  
Ethics and Biotechnology - from BBC
http://www.bbc.co.uk/religion/ethics/animals/biotechnology1.shtml
Plants

Get into Genes - an interactive education program for secondary school students that highlights the application of biotechnology to crop improvement. It provides students with an insight into the relationship between molecular biology, genetics and plant breeding.
http://www.getintogenes.com.au/

Changes in Wild Plants during domestication - Slide show from Horticulture at Louisiana State University
http://www.lsu.edu/horticulture/4083/class2/sld001.htm

CONSEQUENCES OF CLASSICAL PLANT BREEDING FOR PEST RESISTANCE - before and after Mendel, from Donald N. Duvick, Iowa State University
http://www.isb.vt.edu/proceedings99/proceedings.duvick.html

A Comparison between Crop Domestication, Classical Plant Breeding, and Genetic Engineering - abstract of an article
http://intl-crop.scijournals.org/cgi/content/abstract/42/6/1780

The Cabbage Family

Cabbage family images: - enter Brassica oleracea in Google or Yahoo and select Images

Brassica.jpg - black and white jpg image showing variations
http://oak.cats.ohiou.edu/%7Eballardh/pbio475/Adaptation/Brassica.JPG

Ancestral cabbage plant from southern Spain
http://tematico.princast.es/mediambi/siapa/contenidos/images/01Espacios_Especies/flora/brassica.jpg

Corn

Native American History of Corn - from NativeTech: Native American Technology and Art
http://www.nativetech.org/cornhusk/cornhusk.html

Corn as a Crop - from US Department of Agriculture
http://www.aphis.usda.gov/brs/corn.html

Maize - from The Encyclopedia of Mexico: History, History and Culture
http://www.ag.iastate.edu/departments/agronomy/maizearticle.html

Lettuce

Lettuce - Lactuca sativa - Daisy Family - from a gardening site
http://www.selfsufficientish.com/lettuce.htm

Prickly lettuce - the ancestor of modern lettuces is a widespread weed
http://www.carsoncity.k12.mi.us/%7Ehsstudent/wildflowers/pricklylettuce.html

Universal boon to the salad bowl - from Texas A & M University
http://plantanswers.tamu.edu/publications/vegetabletravelers/lettuce.html

Grow Your Own Salad Greens - provides numerous images of lettuce varieties - from University od Wisconsin
http://www.hort.wisc.edu/mastergardener/Features/vegetables/lettuce/lettuce.htm

Lettuce and its relatives - a concise summary of much that is known about lettuce varieties. Could be used for the basis of a class discussion about development of lettuce varieties by selective breeding- from Purdue University.
http://www.hort.purdue.edu/rhodcv/hort410/lettuc/le00001.htm


Kangaroo Paws

Fact Sheet on breeding cultivars - from Gardening Australia
http://www.abc.net.au/gardening/stories/s850734.htm

Animals

Quagga

The Quagga Project - using selective breeding to restore an extinct subspecies of the zebra
http://www.quaggaproject.org/

Quagga Project Breeds Success - from Genome News Network
http://www.genomenewsnetwork.org/articles/10_00/Quagga_project.shtml

A rapid loss of stripes: the evolutionary history of the extinct quagga - DNA extracted from museum specimens, from Quagga Project
http://media1.mweb.co.za/quaggaproject/dna.htm

Improved breeding - from CSIRO Aquaculture, examples of prawns, abalone and oysters
http://www.marine.csiro.au/aquaculture/improvbreed.html

Selective Breeding of Sydney rock oysters - from NSW Fisheries
http://www.fisheries.nsw.gov.au/pages/aquaculture/srrock.htm

Australian Hereford Society - includes information on history, breed profile and cross-breeding
http://www.hereford.com.au/


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Cloning

Plants

Growing Plants from Cuttings - Burke's Backyard Archives
Fact Sheet

Propagation from cuttings - from Australian National Botanic Gardens
http://www.anbg.gov.au/PROPGATE/propagat.htm

Safe use of plant growth hormones - from Australian National Botanic Gardens
http://www.anbg.gov.au/PROPGATE/safeuse.htm

Cloning kit - with instructions from commercial company
http://www.clonekit.com/

Fast Tissue Culture - Laboratory activity for schools includes notes for teachers, from Cambridge University
http://www-saps.plantsci.cam.ac.uk/worksheets/ssheets/ssheet12.htm

Nutriflo Hydroponic Systems - commercial company showing details of equipment used
http://users.bigpond.net.au/nutriflo/"

Plant propagation - from Nutriflo Hydroponic Systems
http://users.bigpond.net.au/nutriflo/prop.htm

Growmore Bio-tech Products - links to pictures of their FACILITIES and examples such as bananas, sugarcane and asparagus
http://www.growmorebiotech.com/product.htm

Fundamentals of Plant Tissue Culture - from Victorian Government
Tissue Culture

Plant Tissue Culture for Home Gardeners - from Horticultural Science & Plant Technology Group, The University of New England
http://www.une.edu.au/agronomy/hort/ptc_for_home_~1.htm
or
http://www.une.edu.au/agronomy/AgSSrHortTCinfo.html

Plant Tissue Culture - from Access Excellence
http://www.accessexcellence.org/LC/ST/st2bgplant.html

Tissue Culture of Woody Plants from Texas A & M University - including impact of the tissue culture industry
http://aggie-horticulture.tamu.edu/tisscult/microprop/woodypl.html

Designing a Plant Micropropagation Laboratory - from Departments of Plant Science and Agricultural Engineering, University of Connecticut
http://aggie-horticulture.tamu.edu/tisscult/microprop/facilities/microlab.html

Transgenic Plants - by John W. Kimball, formerly of Harvard University
http://www.ultranet.com/~jkimball/BiologyPages/T/TransgenicPlants.html

Designer Seeds - from Beyond Discovery,The National Academy of Sciences
http://www.beyonddiscovery.org/content/view.article.asp?a=167

Animals

Animal Cloning - includes material about Dolly the cloned sheep, from RDS, UK
Cloning

Cloning - from The Gene School
http://library.thinkquest.org/19037/clone.html

The mammal copiers - advances in cloning - from NOVA, Australian Academy of Sciences
http://www.science.org.au/nova/043/043key.htm

Cloning Fact Sheet - from Human genome project
http://www.sciam.com/2000/1100issue/1100lanza.html

Australia's Thylacine To Clone or Not to Clone - from Australian Museum
http://www.austmus.gov.au/thylacine/

Extinct animal cloning - interactive from Biotechnology Online
http://www.biotechnologyonline.gov.au/enviro/cloneextinct.cfm

Send in the Clones - from Access Excellence
http://www.accessexcellence.org/WN/SUA09/clone297.html

CLONING SPECIAL REPORT - from New Scientist
http://www.newscientist.com/nsplus/insight/clone/clone.html

CreatorTM Gene Cloning & Expression System - a product that allows gene cloning with illustrations of how it works
http://www.clontech.com/archive/APR00UPD/creator.html

IS IT RIGHT TO CLONE ANIMALS? An ethical fact sheet from The Church of Scotland
http://www.srtp.org.uk/cloninf4.htm

Transgenic Animals - by John W. Kimball, previously of Harvard University
http://www.ultranet.com/~jkimball/BiologyPages/T/TransgenicAnimals.html


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Gene expression

General Introduction to Gene Expression - 84 page pdf document in slide show format  from the Max Planck Institute  includes excellent diagrams
http://www.umich.edu/~newsinfo/Releases/1999/Jul99/r072899.html

The Nobel Prize in Physiology or Medicine 1995 - was awarded to Lewis, Nüsslein-Volhard and Wieschaus for "The genetic control of embryonic development"
http://www.nobel.se/medicine/laureates/1995/illpres/

A Generalization of Theory on the Evolution of Modifier Genes - paper abstract
http://dynamics.org/~altenber/PAPERS/GTEMG/

Introduction to gene expression - from Indiana State University
http://web.indstate.edu/thcme/mwking/gene-regulation.html

Genetics of Childhood Disorders: XIII. Genomic Imprinting: The Indelible Mark of the Gamete - in the Journal of the American Academy of Child and Adolescent Psychiatry
Psychiatry http://www.med.yale.edu/chldstdy/plomdevelop/genetics/00aprgen.htm


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